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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
MCM4
All Species:
40
Human Site:
Y471
Identified Species:
62.86
UniProt:
P33991
Number Species:
14
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P33991
NP_005905.2
863
96558
Y471
S
A
L
A
P
S
I
Y
E
H
E
D
I
K
K
Chimpanzee
Pan troglodytes
XP_528129
863
96543
Y471
S
A
L
A
P
S
I
Y
E
H
E
D
I
K
K
Rhesus Macaque
Macaca mulatta
Dog
Lupus familis
XP_535063
929
104136
Y537
S
A
L
A
P
S
I
Y
E
H
E
D
I
K
K
Cat
Felis silvestris
Mouse
Mus musculus
P49717
862
96718
Y470
S
A
L
A
P
S
I
Y
E
H
E
D
I
K
K
Rat
Rattus norvegicus
NP_387500
862
96552
Y470
S
A
L
A
P
S
I
Y
E
H
E
D
I
K
K
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001515513
863
97108
Y471
S
A
L
A
P
S
I
Y
E
H
E
D
I
K
K
Chicken
Gallus gallus
XP_424376
859
96866
Y467
S
A
L
A
P
S
I
Y
E
H
E
D
I
K
K
Frog
Xenopus laevis
P30664
863
97105
Y471
A
A
L
A
P
S
I
Y
E
H
E
D
I
K
K
Zebra Danio
Brachydanio rerio
NP_944595
750
84021
M381
G
I
Y
R
A
A
P
M
R
L
N
P
R
Q
S
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q26454
866
96592
Y473
R
A
I
A
P
S
I
Y
E
N
D
D
I
K
K
Honey Bee
Apis mellifera
XP_624670
636
71159
Q267
P
A
A
V
L
E
H
Q
I
Q
V
R
P
F
N
Nematode Worm
Caenorhab. elegans
Q21902
759
84917
L390
G
T
A
K
S
Q
L
L
K
F
V
E
Q
V
S
Sea Urchin
Strong. purpuratus
XP_801985
910
101460
I517
R
A
L
A
L
Q
S
I
G
E
N
E
D
C
K
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
P43299
716
80315
A347
G
H
E
D
I
K
K
A
L
L
L
L
L
V
G
Baker's Yeast
Sacchar. cerevisiae
P30665
933
104985
Y531
R
S
I
A
P
S
I
Y
E
L
E
D
V
K
K
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.7
N.A.
87.6
N.A.
94.9
95.1
N.A.
92.4
86.3
85.7
71.3
N.A.
60.1
42.1
28.1
63.3
Protein Similarity:
100
100
N.A.
90
N.A.
97
97.3
N.A.
96.1
93.1
92.9
78.7
N.A.
77.3
54.3
46.9
76.3
P-Site Identity:
100
100
N.A.
100
N.A.
100
100
N.A.
100
100
93.3
0
N.A.
73.3
6.6
0
26.6
P-Site Similarity:
100
100
N.A.
100
N.A.
100
100
N.A.
100
100
100
13.3
N.A.
93.3
6.6
20
33.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
28.9
42.6
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
46.5
62.3
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
0
66.6
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
6.6
86.6
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
7
74
14
74
7
7
0
7
0
0
0
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
7
0
% C
% Asp:
0
0
0
7
0
0
0
0
0
0
7
67
7
0
0
% D
% Glu:
0
0
7
0
0
7
0
0
67
7
60
14
0
0
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
7
0
0
0
7
0
% F
% Gly:
20
0
0
0
0
0
0
0
7
0
0
0
0
0
7
% G
% His:
0
7
0
0
0
0
7
0
0
54
0
0
0
0
0
% H
% Ile:
0
7
14
0
7
0
67
7
7
0
0
0
60
0
0
% I
% Lys:
0
0
0
7
0
7
7
0
7
0
0
0
0
67
74
% K
% Leu:
0
0
60
0
14
0
7
7
7
20
7
7
7
0
0
% L
% Met:
0
0
0
0
0
0
0
7
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
0
0
0
0
0
7
14
0
0
0
7
% N
% Pro:
7
0
0
0
67
0
7
0
0
0
0
7
7
0
0
% P
% Gln:
0
0
0
0
0
14
0
7
0
7
0
0
7
7
0
% Q
% Arg:
20
0
0
7
0
0
0
0
7
0
0
7
7
0
0
% R
% Ser:
47
7
0
0
7
67
7
0
0
0
0
0
0
0
14
% S
% Thr:
0
7
0
0
0
0
0
0
0
0
0
0
0
0
0
% T
% Val:
0
0
0
7
0
0
0
0
0
0
14
0
7
14
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
7
0
0
0
0
67
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _